10. Pvd1060 - M. Perse -

نویسندگان

  • M. Perše
  • A. Cerar
چکیده

Epidemiological and experimental studies indicate that environmental and dietary factors are probably important determinants of colorectal cancer (CRC). Among dietary factors alcohol intake has been shown to be associated with an increased risk of CRC (1). A large number of epidemiologic studies have examined the possible association of beer and ethanol ingestion on CRC risk. As a result, some epidemiological studies have shown a positive association between alcohol or beer consumption and CRC but the other have not (1-8). Finally, to evaluate the effect of alcohol on CRC under defined experimental conditions experiments on animal models have been performed (9-14). Recently, Perez-Holanda and co-workers conducted experiment evaluating the effect of ethanol consumption on 1,2 dimethylhydrazine (DMH) rat model to contribute to understanding the conflicting epidemiological results (15). Unfortunately, results of ethanol studies using DMH model are not applicable for comparison of epidemiological results (6,13,16,17). Therefore, we decided to briefly summarize and discuss previous work at that field to emphasize the inappropriateness of DMH rat model in ethanol studies. Dimethylhydrazine model is not appropriate for evaluating effect of ethanol on colorectal cancer

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تاریخ انتشار 2007